|Full Name||sialic acid binding Ig-like lectin 12|
|Product Description||Rabbit Polyclonal antibody to SIGLEC12 (sialic acid-binding Ig-like lectin 12)|
|Background||Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq]|
|Synonyms||FLJ38600 antibody, S2V antibody, SIGLECL1 antibody, SLG antibody, Siglec-XII antibody, SIGLEC12 antibody, sialic acid-binding Ig-like lectin 12 antibody, SIGLEC-like 1 antibody, sialic acid-binding Ig-like lectin-like 1 antibody, sialic acid binding Ig-like lectin 12 antibody|
|Cellular Localization||Membrane; Single-pass type I membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human SIGLEC12. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Chimpanzee (96%)|