|Full Name||sirtuin 1|
|Product Description||Rabbit Polyclonal antibody to SIRT1 (sirtuin 1)|
|Background||This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq]|
|Synonyms||SIR2L1 antibody, SIRT1 antibody, hSIR2 antibody, sirtuin type 1 antibody, SIR2alpha antibody, NAD-dependent deacetylase sirtuin-1 antibody, SIR2-like protein 1 antibody, sir2-like 1 antibody, hSIRT1 antibody, sirtuin 1 antibody|
|Cellular Localization||Nucleus |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human SIRT1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Human (100%)|