| Full Name | solute carrier family 7 (amino acid transporter, L-type), member 8 |
| Product Description | Mouse monoclonal antibody [5A9] to SLC7A8 |
| Background | Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney. |
| Synonyms | LPIPC1, SLC7A8, LPI-PC1, LAT2, LPI PC1 |
| Specificity | GTX83618 is specific for human SLC7A8. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Name | 5A9 |
| Target | SLC7A8 |
| Isotype | IgG1 |
| Immunogen | Protein expressed in 293T cell transfected with human SLC7A8 expression vector . |
| Antigen Species | Human |
| Species Reactivity | Human |