|Full Name||lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)|
|Product Description||Goat polyclonal antibody to SLP76|
|Background||SLP76 (SH2 domain containing leukocyte protein of 76 kDa) is a hematopoietic cell-specific adaptor protein that is crucial for T-cell receptor (TCR) signaling, hemostasis and platelet function. TCR ligation and fibrinogen binding to integrin alpha 2 beta 3 stimulates the phosphorylation of the tyrosine residues in the amino terminus, and facilitates SLP76 binding to the SH2 domain of Vav, which can activate JNK. SLP76 also comprises a proline-rich domain region that associates with the SH3 domain of Grb2 linking SLP76 to the Ras to Raf to ERK1 & 2 signaling pathway, LAT, PLC gamma, Fyn-binding protein (SLAP130), the SH2 containing phosphatase 1 and Nck, which mediates the regulation of cytoskeletal actin polymerization. Phosphorylation of tyrosine 145 has been shown to be important for optimal SLP76 function.|
|Synonyms||SLP76 / LCP2, SH2 domain-containing leukocyte protein of 76kD, lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa), 76 kDa tyrosine phosphoprotein, lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein o, SH2 domaincontaining leukocyte protein of76kD, lymphocyte cytosolic protein2 (SH2 domain containing leukocyte protein o, lymphocyte cytosolic protein2 (SH2 domain containing leukocyte protein of76kDa)|
|Specificity||This antibody is specific for SLP76.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Dog, Pig, Bovine|