| Full Name | SMAD family member 2 |
| Background | The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq] |
| Synonyms | JV18 antibody, JV18-1 antibody, MADH2 antibody, MADR2 antibody, MGC22139 antibody, MGC34440 antibody, hMAD-2 antibody, hSMAD2 antibody, SMAD2 antibody, mother against DPP homolog 2 antibody, "SMAD, mothers against DPP homolog 2 antibody", MAD homolog 2 antibody, mothers against decapentaplegic homolog 2 antibody, Sma- and Mad-related protein 2 antibody, SMAD family member 2 antibody |
| Cellular Localization | Cytoplasm , Nucleus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human SMAD2. The exact sequence is proprietary. |
| Antigen Species | Human |
| Species Reactivity | Human, Mouse, Rat |
Predicted Cross Reactivity species  Predicted cross-reactivity:
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
| Zebrafish, Xenopus laevis, Pig, Chicken, Rhesus Monkey, Bovine |
| Predict Reactivity Note | Zebrafish (97%), Xenopus laevis (99%), Pig (100%), Chicken (99%), Rhesus Monkey (100%), Bovine (99%) |
| Conjugation | Unconjugated |