Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||23 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLaS3 , HepG2 , Molt-4 , Raji|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||synaptosomal-associated protein, 23kDa|
|Product Description||Rabbit Polyclonal antibody to SNAP23 (synaptosomal-associated protein, 23kDa)|
|Background||Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq]|
|Synonyms||HsT17016 antibody, SNAP-23 antibody, SNAP23A antibody, SNAP23B antibody, SNAP23 antibody, vesicle-membrane fusion protein SNAP-23 antibody, synaptosomal-associated protein 23 antibody, "synaptosomal-associated protein, 23kDa antibody"|
|Cellular Localization||Cell membrane; Peripheral membrane protein , Cell junction , synapse , synaptosome |
|Immunogen||Full length human SNAP23 Recombinant protein.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Rabbit, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (87%), Rat (88%), Pig (87%), Rabbit (88%), Chicken (82%), Rhesus Monkey (96%), Bovine (86%)|