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1 .GTX23691 SOCS1 antibody

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SOCS1 antibody


  • Host / ClonalityRabbit Polyclonal
  • ApplicationsELISA, IP, WB
  • Species reactivityHuman
Cat No: GTX23691
Package Price Qty
50 μgUSD 339.00
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  • Datasheet
  • Application Information: SOCS1 antibody

Catalog Number GTX23691
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Product Name SOCS1 antibody
See all SOCS1 products
ApplicationsELISA, IP, WB
Application NoteImmunoprecipitation: use at a concentration of 3.0 - 5.0 μg / extract from 10^7 cells. Western Blotting: use at a concentration of 0.5 - 2.0 μg/ml. ELISA: use at a concentration of 0.1 - 1.0 μg/ml. Optimal dilutions / concentrations should be determined by the end user. By Western blot, this antibody detects a band of approximately 24 kDa in GH treated HEK 293 cell lysate, which corresponds to the predicted molecular weight of SOCS 1. Samples were boiled prior to subject 10% SDS-polyacrylamide gelelectrophoresis.
Form SuppliedLiquid
Concentration0.2 mg/ml (Please refer to the vial label for the specific concentration)
PurificationImmunogen affinity purified

  • Specifications: SOCS1 antibody

Full Namesuppressor of cytokine signaling 1
BackgroundAccumulating evidence has demonstrated that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family that have been identified; they are SOCS 1, 2, 3, 4, 5, 6, 7 and CIS. Structurally, the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif named the SOCS box. SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines. Once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS 1 inhibition of signal transduction appears to occur by binding to and inhibiting the catalytic activity of members of JAK family of cytoplasmic kinases (direct JAK2 kinas inhibition). Biochemical characterization as well as gene disruption studies indicate that SOCS 1 is an important negative regulator of JAK-STAT signal pathway. SOCS 1 is also called JAB SSI 1 or TIP3 (Tec-Interacting Protein).
SynonymsSSI-1, O15524, SOCS1, CISH1, CIS1, SSI1, JAB, 8651, TIP3, 603597, SOCS-1, SSI 1, SOCS 1
HostRabbit
ClonalityPolyclonal
IsotypeIgG
ImmunogenSynthetic peptide: VLRDYLSSFPFQI, corresponding to amino acids 199-211of human SOCS 1 or 200-212 of the mouse SOCS 1.
Antigen SpeciesHuman
Species ReactivityHuman
ConjugationUnconjugated

  • Storage Conditions: SOCS1 antibody

Storage BufferPBS with 0.02% sodium azide
Storage InstructionKeep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
NotesFor In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
ResearchArea
  • Disease Related > Alzheimer's disease
  • Disease Related > Cardiovascular > Heart > Heart disease
  • Disease Related > Diabetes
  • Immunology > Autoimmunity > Autoimmune diseases > Diabetes
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SOCS1 antibody validated data
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