|Full Name||sperm associated antigen 6|
|Product Description||Rabbit Polyclonal antibody to SPAG6 (sperm associated antigen 6)|
|Background||The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined. [provided by RefSeq]|
|Synonyms||DKFZp434I153 antibody, MGC26276 antibody, Repro-SA-1 antibody, pf16 antibody, SPAG6 antibody, axoneme central apparatus protein antibody, protein PF16 homolog antibody, sperm-associated antigen 6 antibody, sperm flagellar protein antibody, sperm associated antigen 6 antibody|
|Cellular Localization||Cytoplasm , cytoskeleton , Cell projection , cilium , flagellum |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human SPAG6. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Xenopus laevis, Pig, Chicken, Chimpanzee, Bovine|
|Predict Reactivity Note||Mouse (91%), Rat (95%), Xenopus laevis (87%), Pig (97%), Chicken (82%), Chimpanzee (100%), Bovine (96%)|