Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||48 kDa (note)
|Positive Controls||Raji , K562 , HL-60 , NCI-H929 , HepG2 , HepG2 (3 μM Thapsigargin for 12 hr)|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||sequestosome 1|
|Product Description||Rabbit Polyclonal antibody to SQSTM1 (sequestosome 1)|
|Background||This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq]|
|Synonyms||A170 antibody, OSIL antibody, PDB3 antibody, ZIP3 antibody, p60 antibody, p62 antibody, p62B antibody, SQSTM1 antibody, EBI3-associated protein p60 antibody, ubiquitin-binding protein p62 antibody, EBI3-associated protein of 60 kDa antibody, oxidative stress induced like antibody, phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa antibody, EBIAP antibody, phosphotyrosine independent ligand for the Lck SH2 domain p62 antibody, sequestosome-1 antibody, sequestosome 1 antibody|
|Cellular Localization||Cytoplasm , Late endosome , Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human SQSTM1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Sheep, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (88%), Rat (88%), Sheep (93%), Rhesus Monkey (98%), Bovine (92%)|