Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||48 kDa (note)
|Positive Controls||HepG2 , A549 , H1299 , Neuro2A , C8D30 , NIH-3T3 , Raw264.7 , C2C12 , PC-12|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||sequestosome 1|
|Product Description||Rabbit Polyclonal antibody to SQSTM1 (sequestosome 1)|
|Background||This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq]|
|Synonyms||p62 Antibody , A170 Antibody , OSIL Antibody , sequestosome 1 Antibody , p62B Antibody , p60 Antibody , ZIP3 Antibody , PDB3 Antibody|
|Cellular Localization||Cytoplasm , Late endosome , Nucleus |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human SQSTM1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Sheep, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Sheep (100%), Rhesus Monkey (100%), Bovine (100%)|