|Applications||ICC/IF, IHC-P, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||61 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLa , HepG2 , Molt-4 , Rat liver|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||scavenger receptor class B, member 1|
|Product Description||Rabbit polyclonal antibody to SR-BI (scavenger receptor class B, member 1)|
|Background||Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester.|
|Synonyms||CD36L1 antibody, CLA-1 antibody, CLA1 antibody, HDLQTL6 antibody, MGC138242 antibody, SR-BI antibody, SRB1 antibody, SCARB1 antibody, "CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1 antibody", CD36 and LIMPII analogous 1 antibody, scavenger receptor class B member 1 antibody, scavenger receptor class B type III antibody, "scavenger receptor class B, member 1 antibody"|
|Cellular Localization||Cell membrane; Multi-pass membrane protein , Membrane , caveola; Multi-pass membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human SR-BI. The exact sequence is proprietary.|
|Species Reactivity||Human, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Pig, Rabbit, Bovine|
|Predict Reactivity Note||Mouse (83%), Pig (91%), Rabbit (87%), Bovine (86%)|