|Full Name||sterol regulatory element binding transcription factor 1|
|Product Description||Rabbit polyclonal antibody to SREBP-1 (sterol regulatory element binding transcription factor 1)|
|Background||This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||SREBP-1c antibody, SREBP1 antibody, bHLHd1 antibody, SREBF1 antibody, class D basic helix-loop-helix protein 1 antibody, SREBP-1 antibody, sterol regulatory element-binding protein 1 antibody, sterol regulatory element binding transcription factor 1 antibody|
|Cellular Localization||Endoplasmic reticulum membrane; Multi-pass membrane protein , Golgi apparatus membrane; Multi-pass membrane protein , Cytoplasmic vesicle , COPII-coated vesicle membrane; Multi-pass membrane protein , Processed sterol regulatory element-binding protein 1:|
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human SREBP1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Rat, Dog, Pig, Bovine|
|Predict Reactivity Note||Human (100%), Mouse (89%), Rat (87%), Dog (90%), Pig (86%), Bovine (85%)|