Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||60 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji , mouse brain|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||karyopherin alpha 1 (importin alpha 5)|
|Product Description||Rabbit Polyclonal antibody to SRP1 (karyopherin alpha 1 (importin alpha 5))|
|Background||Recombination activating proteins RAG1 and RAG2 regulate and mediate V(D)J recombination, the process by which genes for immunoglobulins and T-cell receptors are generated. Several other ubiquitously expressed proteins are thought to be recruited in the recombination process. Among these are the genes affected in severe combined immune deficiency and genes involved in ds-DNA break repair. The protein encoded by this gene interacts with RAG1 and may play a role in V(D)J recombination. Two transcript variants, one protein-coding and the other not, have been found for this gene. [provided by RefSeq]|
|Synonyms||IPOA5 antibody, NPI-1 antibody, RCH2 antibody, SRP1 antibody, KPNA1 antibody, SRP1-beta antibody, karyopherin subunit alpha-1 antibody, recombination activating gene cohort 2 antibody, RAG cohort protein 2 antibody, importin subunit alpha-1 antibody, importin alpha 5 antibody, nucleoprotein interactor 1 antibody, importin-alpha-S1 antibody, karyopherin alpha 1 (importin alpha 5) antibody|
|Cellular Localization||Cytoplasm , Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human SRP1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Pig, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (97%), Pig (98%), Chicken (93%), Rhesus Monkey (99%), Bovine (98%)|