SSRP1 antibody [N1N3]
|Applications||IHC-P, IP, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
| Immunoprecipitation||Assay-dependent dilution
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||81 kDa (note)
|Positive Controls||293T , A431 , HeLa , HepG2 , Jurkat , Molt-4|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||structure specific recognition protein 1|
|Product Description||Rabbit polyclonal antibody to SSRP1 (structure specific recognition protein 1)|
|Background||The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq]|
|Synonyms||FACT antibody, FACT80 antibody, T160 antibody, SSRP1 antibody, hSSRP1 antibody, chromatin-specific transcription elongation factor 80 kDa subunit antibody, structure-specific recognition protein 1 antibody, facilitates chromatin transcription complex 80 kDa subunit antibody, FACT 80 kDa subunit antibody, cisplatin-DNA SSRP antibody, recombination signal sequence recognition protein 1 antibody, high mobility group box antibody, FACT complex subunit SSRP1 antibody, facilitates chromatin transcription complex subunit SSRP1 antibody, facilitates chromatin remodeling 80 kDa subunit antibody, FACTp80 antibody, structure specific recognition protein 1 antibody|
|Cellular Localization||Nucleus |
|Specificity||Knockdown/Knockout validation was supported by references (PMID:26991004)|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human SSRP1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Xenopus laevis, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (100%), Rat (100%), Xenopus laevis (91%), Chicken (99%), Rhesus Monkey (100%), Bovine (100%)|