|Full Name||signal transducer and activator of transcription 2, 113kDa|
|Product Description||Rabbit Polyclonal antibody to STAT2 (signal transducer and activator of transcription 2, 113kDa)|
|Background||The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. [provided by RefSeq]|
|Synonyms||ISGF-3 antibody, MGC59816 antibody, P113 antibody, STAT113 antibody, STAT2 antibody, signal transducer and activator of transcription 2 antibody, interferon alpha induced transcriptional activator antibody, signal transducer and activator of transcription 2, 113kDa antibody|
|Cellular Localization||Cytoplasm , Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human STAT2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Pig, Rhesus Monkey|
|Predict Reactivity Note||Pig (80%), Rhesus Monkey (97%)|