|Full Name||signal transducer and activator of transcription 3 (acute-phase response factor)|
|Product Description||Rabbit Polyclonal antibody to STAT3 (signal transducer and activator of transcription 3 (acute-phase response factor))|
|Background||The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq]|
|Synonyms||APRF antibody, FLJ20882 antibody, HIES antibody, MGC16063 antibody, STAT3 antibody, acute-phase response factor antibody, DNA-binding protein APRF antibody, signal transducer and activator of transcription 3 antibody, signal transducer and activator of transcription 3 (acute-phase response factor) antibody|
|Specificity||GTX110587 is recommended for WB application in mouse samples only. If you would like to use it on human samples, please refer to GTX104616|
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human STAT3. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Zebrafish, Japanese medaka, Pig, Chicken, Bovine|
|Predict Reactivity Note||Rat (100%), Zebrafish (82%), Japanese medaka (81%), Pig (100%), Chicken (93%), Bovine (98%)|