|Full Name||signal transducer and activator of transcription 5A|
|Product Description||Rabbit polyclonal antibody to STAT5A (signal transducer and activator of transcription 5A)|
|Background||The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. [provided by RefSeq]|
|Synonyms||MGF antibody, STAT5 antibody, STAT5A antibody, signal transducer and activator of transcription 5A antibody|
|Cellular Localization||Cytoplasm , Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human STAT5A. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Xenopus laevis, Pig, Sheep, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (96%), Rat (96%), Xenopus laevis (87%), Pig (98%), Sheep (97%), Rhesus Monkey (100%), Bovine (97%)|