|Full Name||signal transducer and activator of transcription 5B|
|Product Description||Rabbit Polyclonal antibody to STAT5B (signal transducer and activator of transcription 5B)|
|Background||The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq]|
|Synonyms||signal transducer and activator of transcription 5B Antibody , STAT5 Antibody|
|Cellular Localization||Cytoplasm (By similarity) , Nucleus (By similarity) |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human STAT5B. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Bovine|
|Predict Reactivity Note||Mouse (100%), Rat (100%), Pig (100%), Bovine (100%)|