|Full Name||signal transducer and activator of transcription 6, interleukin-4 induced|
|Product Description||Rabbit Polyclonal antibody to STAT6 (signal transducer and activator of transcription 6, interleukin-4 induced)|
|Background||The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. [provided by RefSeq]|
|Synonyms||D12S1644 antibody, IL-4-STAT antibody, STAT6B antibody, STAT6C antibody, STAT6 antibody, transcription factor IL-4 STAT antibody, STAT, interleukin4-induced antibody, signal transducer and activator of transcription 6 antibody, signal transducer and activator of transcription 6, interleukin-4 induced antibody|
|Cellular Localization||Cytoplasm , Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human STAT6. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Pig, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (80%), Pig (90%), Rhesus Monkey (96%), Bovine (89%)|