|Full Name||SCL/TAL1 interrupting locus|
|Product Description||Rabbit polyclonal antibody to STIL (SCL/TAL1 interrupting locus)|
|Background||This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||DKFZp686O09161 antibody, MCPH7 antibody, SIL antibody, STIL antibody, SCL-interrupting locus protein antibody, TAL-1-interrupting locus protein antibody, SCL/TAL1 interrupting locus antibody|
|Cellular Localization||Cytoplasm , cytosol |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human STIL. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Bovine|
|Predict Reactivity Note||Human (100%), Mouse (81%), Bovine (82%)|