|Full Name||stromal interaction molecule 1|
|Product Description||Rabbit Polyclonal antibody to STIM1 (stromal interaction molecule 1)|
|Background||This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene.|
|Synonyms||D11S4896E antibody, GOK antibody, STIM1 antibody, stromal interaction molecule 1 antibody|
|Cellular Localization||Cell membrane; Single-pass type I membrane protein , Endoplasmic reticulum membrane; Single-pass type I membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human STIM1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Rat, Pig, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Human (100%), Rat (91%), Pig (88%), Rhesus Monkey (98%), Bovine (91%)|