Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||56 kDa (note)
|Positive Controls||293T , A431 , THP-1 , NCI-H929 , 293T mock , 293T transfected STK3|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||serine/threonine kinase 3|
|Product Description||Rabbit Polyclonal antibody to STK3 (serine/threonine kinase 3)|
|Background||Protein kinase activation is a frequent response of cells to treatment with growth factors, chemicals, heat shock, or apoptosis-inducing agents. This protein kinase activation presumably allows cells to resist unfavorable environmental conditions. The yeast 'sterile 20' (Ste20) kinase acts upstream of the mitogen-activated protein kinase (MAPK) cascade that is activated under a variety of stress conditions. MST2 was identified as a kinase that is activated by the proapoptotic agents straurosporine and FAS ligand (MIM 134638) (Taylor et al., 1996 [PubMed 8816758]; Lee et al., 2001 [PubMed 11278283]).[supplied by OMIM]|
|Synonyms||FLJ90748 antibody, KRS1 antibody, MST2 antibody, STK3 antibody, "serine/threonine kinase 3 (STE20 homolog, yeast) antibody", MST-2 antibody, serine/threonine-protein kinase 3 antibody, "serine/threonine kinase 3 (Ste20, yeast homolog) antibody", serine/threonine-protein kinase Krs-1 antibody, mammalian STE20-like protein kinase 2 antibody, STE20-like kinase MST2 antibody, serine/threonine kinase 3 antibody|
|Cellular Localization||Cytoplasm (By similarity) , Nucleus (By similarity) |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human STK3. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Xenopus laevis, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (93%), Rat (93%), Xenopus laevis (87%), Chicken (94%), Rhesus Monkey (99%), Bovine (99%)|