SUCLA2 antibody [N2C3]
|Applications||ICC/IF, IHC-P, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||50 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji , mouse brain|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||succinate-CoA ligase, ADP-forming, beta subunit|
|Product Description||Rabbit Polyclonal antibody to SUCLA2 (succinate-CoA ligase, ADP-forming, beta subunit)|
|Background||Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq]|
|Synonyms||A-BETA antibody, MTDPS5 antibody, SCS-betaA antibody, SUCLA2 antibody, succinyl-CoA synthetase beta-A chain antibody, mitochondrial succinyl-CoA ligase [ADP-forming] subunit beta antibody, renal carcinoma antigen NY-REN-39 antibody, ATP-specific succinyl-CoA synthetase subunit beta antibody, "ATP-specific succinyl-CoA synthetase, beta subunit antibody", "succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial antibody", "succinate-CoA ligase, ADP-forming, beta subunit antibody"|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human SUCLA2. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Zebrafish, Xenopus laevis, Chicken, Bovine|
|Predict Reactivity Note||Rat (88%), Zebrafish (81%), Xenopus laevis (85%), Chicken (90%), Bovine (92%)|