|Full Name||suppressor of variegation 3-9 homolog 2 (Drosophila)|
|Product Description||Goat polyclonal antibody to SUV39H2|
|Background||Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher order chromatin organization during spermatogenesis. |
|Synonyms||suppressor of variation 3-9 (Drosophila) homolog 2 (Drosophila), suppressor of variation39 (Drosophila) homolog2 (Drosophila), uppressor of variegation39 homolog2 (Drosophila), RP11-2K17.2, suppressor of variegation39 homolog2, suppressor of variegation 39 homolog 2, uppressor of variegation 39 homolog 2 (Drosophila), KMT1B, RP112K17.2, KMT1, SUV39H2, uppressor of variegation 3-9 homolog 2 (Drosophila)|
|Cellular Localization||Associates with centromeric constitutive heterochromatin. |
|Specificity||This antibody is specific for SUV39H2.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Dog, Pig, Bovine|