|Full Name||SWAP switching B-cell complex 70kDa subunit|
|Product Description||Goat polyclonal antibody to SWAP70|
|Background||Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion. |
|Synonyms||SWAP70 protein, KIAA0640 protein, HSPC321, FLJ39540, SWAP switching Bcell complex 70kDa subunit, KIAA0640, SWAP-70, SWAP switching B-cell complex 70kDa subunit, SWAP-70 protein, SWAP70, SWAP switching Bcell complex70kDa subunit, SWAP 70, SWAP 70 protein|
|Cellular Localization||In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localize|
|Specificity||This antibody is specific for SWAP70.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.