|Product Description||Rabbit Polyclonal antibody to Sclerostin |
|Background||Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq]|
|Synonyms||VBCH Antibody , CDD Antibody , SOST Antibody , sclerostin Antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Sclerostin. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (89%), Rat (92%), Rhesus Monkey (97%), Bovine (94%)|