|Full Name||pituitary tumor-transforming 1|
|Product Description||Rabbit Polyclonal antibody to Securin (pituitary tumor-transforming 1)|
|Background||The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. [provided by RefSeq]|
|Synonyms||EAP1 antibody, HPTTG antibody, MGC126883 antibody, MGC138276 antibody, PTTG antibody, TUTR1 antibody, PTTG1 antibody, pituitary tumor-transforming gene 1 protein antibody, ESP1-associated protein 1 antibody, securin antibody, tumor-transforming protein 1 antibody, pituitary tumor-transforming 1 antibody|
|Cellular Localization||Cytoplasm , Nucleus |
|Immunogen||Full length human Securin Recombinant protein.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rhesus Monkey, Chimpanzee, Bovine|
|Predict Reactivity Note||Rhesus Monkey (98%), Chimpanzee (99%), Bovine (85%)|