|Full Name||24-dehydrocholesterol reductase|
|Product Description||Rabbit Polyclonal antibody to Seladin 1 (24-dehydrocholesterol reductase)|
|Background||This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq]|
|Synonyms||DCE antibody, KIAA0018 antibody, Nbla03646 antibody, SELADIN1 antibody, seladin-1 antibody, DHCR24 antibody, 3 beta-hydroxysterol delta 24-reductase antibody, seladin 1 antibody, delta(24)-sterol reductase antibody, diminuto/dwarf1 homolog antibody, 3-beta-hydroxysterol delta-24-reductase antibody, desmosterol-to-cholesterol enzyme antibody, selective AD indicator 1 antibody, 24-dehydrocholesterol reductase antibody|
|Cellular Localization||Endoplasmic reticulum membrane , Golgi apparatus membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Seladin 1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Zebrafish, Pig, Chicken, Bovine|
|Predict Reactivity Note||Zebrafish (82%), Pig (95%), Chicken (80%), Bovine (96%)|