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1 .GTX18792 Serum Amyloid A antibody [585]

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Serum Amyloid A antibody [585]


  • Host / ClonalityMouse Monoclonal
  • Clone Name585
  • ApplicationsELISA, WB
  • Species reactivityHuman
Cat No: GTX18792
Package Price Qty
250 μgUSD 319.00
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  • Datasheet
  • Application Information: Serum Amyloid A antibody [585]

Catalog Number GTX18792
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Product Name Serum Amyloid A antibody [585]
See all Serum Amyloid A products
ApplicationsELISA, WB
Application NoteFor ELISA: Use at an assay dependent dilution. For WB: Use at a concentration of 0.1 - 0.5 μg/ml. Detects a band of approximately 12 kDa (predicted molecular weight: 14 kDa). Optimal dilutions/concentrations should be determined by the researcher.
Concentration1 mg/ml (Please refer to the vial label for the specific concentration)
PurificationProtein G purified

  • Specifications: Serum Amyloid A antibody [585]

Full Nameserum amyloid A1
BackgroundThe serum amyloid A family comprises a number of differentially expressed apolipoproteins, acute-phase SAA1 and SAA2, the former being the major component in plasma and constitutive SAAs. Although the liver is the primary site of synthesis of both SAA types extrahepatic production has been reported. The in vivo concentrations increase by as much as 1000 fold during inflammation. Several studies have expressed its importance in the diagnosis and monitoring of various diseases. Pathological SAA values are often detected in association with normal CRP concentrations; SAA rises earlier and more sharply than CRP. Recently, a broader view of SAA expression and function has been emerging. Expression studies show production of SAA proteins in histologically normal, atherosclerotic, Alzheimer, inflammatory, and tumour tissues. SAA has been found to have binding sites for high density lipoproteins, calcium, laminin, and heparin/heparin sulphate. Also adhesion motifs were identified and new functions affecting cell adhesion, migration, proliferation, and aggregation were discovered. These findings emphasize the importance of SAA in various physiological and pathological processes including inflammation, atherosclerosis, thrombosis, AA-amyloidosis, rheumatoid arthritis, and neoplasia. SAA has also a number of immunomodulatory roles, it can induce chemotaxis and adhesion molecule expression, has cytokine-like properties and can promote the upregulation of metalloproteinases. It enhances the binding of high density lipoprotein to macrophages and thus helps in the delivery of lipids to sites of injury for use in tissue repair, it is thus thought to be an integral part of the disease process.
Synonyms6288, MGC111216, 104750, SAA, PIG4, TP53I4, SAA1, P02735
Cellular LocalizationSecreted
SpecificityReacts with endogneous and recombinant human SAA. Does not cross-react with other human cytokines or growth factors tested such as IL1?, IL8, MCAF, TGF? and EGF.
HostMouse
ClonalityMonoclonal
Clone Name585
IsotypeIgG2b
ImmunogenHighly purified recombinant human SAA (MW: 12 kDa)
Light Chainkappa
Antigen SpeciesHuman
Species ReactivityHuman
ConjugationUnconjugated

  • Storage Conditions: Serum Amyloid A antibody [585]

Storage BufferPhosphat-buffered saline, pH 7.2, containing no preservatives
Storage InstructionKeep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
NotesFor In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
ResearchArea
  • Cell Biology > Cell adhesion > Regulation > Positive regulation
  • Disease Related > Alzheimer's disease
  • Disease Related > Cardiovascular > Heart > Heart disease
  • Immunology > Autoimmunity > Autoimmune diseases > Rheumatoid Arthritis
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Serum Amyloid A antibody [585] validated data
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