|Full Name||sortilin-related receptor, L(DLR class) A repeats containing|
|Product Description||Rabbit polyclonal antibody to SorLA (sortilin-related receptor, L(DLR class) A repeats-containing)|
|Background||This gene encodes a protein that belongs to the families of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins, of low density lipoprotein receptor (LDLR) proteins, and of fibronectin type III repeats proteins. In addition to VPS10, LDLR and fibronectin type 3 domains, this protein also includes an epidermal growth factor precursor-like module, a single transmembrane segment and a cytoplasmic tail with features similar to endocytosis- and sorting-competent receptors. Members of the VPS10 domain-containing receptor family are large with many exons but the CDS lengths are usually less than 3700 nt; this gene is an exception to the pattern with a CDS length greater than 6600 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. The encoded protein is mainly intracellular and localizes in the paranuclear compartment. It is synthesized as a preproprotein, and when the propeptide is still attached, no binding occurs to the VPS10 domain. This gene is strongly expressed in the central nervous system. [provided by RefSeq]|
|Synonyms||C11orf32 antibody, FLJ21930 antibody, FLJ39258 antibody, LR11 antibody, LRP9 antibody, SORLA antibody, SorLA-1 antibody, gp250 antibody, SORL1 antibody, low-density lipoprotein receptor relative with 11 ligand-binding repeats antibody, LDLR relative with 11 ligand-binding repeats antibody, "sortilin-related receptor, L(DLR class) A repeats-containing antibody", mosaic protein LR11 antibody, sortilin-related receptor antibody, sorting protein-related receptor containing LDLR class A repeats antibody, "sortilin-related receptor, L(DLR class) A repeats containing antibody"|
|Cellular Localization||Membrane; Single-pass type I membrane protein |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human SorLA. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Rat, Rabbit, Chicken, Bovine|
|Predict Reactivity Note||Human (100%), Mouse (100%), Rat (100%), Rabbit (100%), Chicken (100%), Bovine (100%)|