|Full Name||sortilin 1|
|Product Description||Rabbit Polyclonal antibody to Sortilin 1 (sortilin 1)|
|Background||This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins. [provided by RefSeq]|
|Synonyms||Gp95 antibody, LDLCQ6 antibody, NT3 antibody, SORT1 antibody, neurotensin receptor 3 antibody, 100 kDa NT receptor antibody, sortilin antibody, glycoprotein 95 antibody, NTR3 antibody, sortilin 1 antibody|
|Cellular Localization||Membrane; Single-pass type I membrane protein , Endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential) , Endosome membrane; Single-pass type I membrane protein (Potential) , Golgi apparatus , Golgi stack membrane; Single-pass type|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Sortilin 1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rat (90%)|