|Product Description||Rabbit Polyclonal antibody to Spastin (spastin)|
|Background||This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequences have not been determined. Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4. [provided by RefSeq]|
|Synonyms||ADPSP Antibody , FSP2 Antibody , SPG4 Antibody , SPAST Antibody , spastin Antibody|
|Cellular Localization||Membrane; Single-pass membrane protein (Potential) , Centrosome , Cytoplasm , cytoskeleton , perinuclear region , Endoplasmic reticulum , Endosome , Nucleus , Spindle |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Spastin. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Pig, Bovine|
|Predict Reactivity Note||Rat (90%), Pig (88%), Bovine (91%)|