|Product Description||Rabbit polyclonal antibody to Spastin|
|Background||This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequences have not been determined. Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4. [provided by RefSeq, Jul 2008]|
|Synonyms||ADPSP Antibody , FSP2 Antibody , spastin Antibody , SPAST Antibody , SPG4 Antibody|
|Specificity||This antibody recognizes an epitope between amino acids 130-142 of human spastin. The antibody has low identitiy with the Spastin 171-185 peptide, Spastin 204-215 peptide, and Spastin 561-573 peptide.|
|Immunogen||Synthetic peptide corresponding to the amino acids 130 - 142 human spastin conjugated to Keyhole limpet Haemocyanin.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
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