|Full Name||spleen tyrosine kinase|
|Product Description||Goat polyclonal antibody to Spleen tyrosine kinase / Syk|
|Background||Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-348 and Tyr-352. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion (By similarity). Phosphorylates USP25 and regulates its intracellular levels. |
|Synonyms||SYK, OTTHUMP00000021628, OTTHUMP00000021629, spleen tyrosine kinase, Spleen tyrosine kinase / SYK, FLJ25043, HGNC:11491, DKFZp313N1010, FLJ37489|
|Specificity||This antibody is specific for Spleen tyrosine kinase / Syk.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Dog, Pig, Bovine|