|Full Name||syntaxin 1A (brain)|
|Product Description||Rabbit polyclonal antibody to syntaxin 1A (syntaxin 1A (brain))|
|Background||Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor (MIM 600565) which produces explosive exocytosis (Zhang et al., 1995 [PubMed 7622072]).[supplied by OMIM]|
|Synonyms||HPC-1 antibody, P35-1 antibody, STX1 antibody, SYN1A antibody, STX1A antibody, syntaxin-1A antibody, neuron-specific antigen HPC-1 antibody, syntaxin 1A (brain) antibody|
|Cellular Localization||Cell membrane; Single-pass type IV membrane protein , Isoform 2: Secreted |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Syntaxin 1a. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (100%), Rat (100%), Rhesus Monkey (100%), Bovine (100%)|