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Syntaxin antibody [4H256]

Orthogonal
Anti-Syntaxin antibody [4H256] used in Western Blot (WB). GTX18010

Cat. No. GTX18010

Reference 2

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 4H256

Isotype

 IgG1

Application

 WB

Reactivity

 Human, Mouse, Rat, Bovine, Cat, Hamster, Pig, Xenopus laevis
Package
50 μg ($399)
See all Syntaxin products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
Not tested in other applications.

Calculated MW

33 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 0.1mM PMSF, 50% Glycerol

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synaptic vesicle-containing fractions that were immunoprecipitated from human brain homogenates using anti-human Synaptophysin monoclonal antibodies.

Purification

Protein G purified

Conjugation

Unconjugated

RRID

AB_423022

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

HPC1 , P351 , STX1 , STX1A , SYN1A , syntaxin 1A , Syntaxin 1a , STX1a

Cellular Localization

Cytoplasmic vesicle,Secretory vesicle,Synaptic vesicle membrane,Cell junction,Synapse,Synaptosome,Cell membrane,Secreted

Background

This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

Database

Research Area

DATA IMAGES

Anti-Syntaxin antibody [4H256] used in Western Blot (WB). GTX18010

GTX18010 WB Image

Orthogonal

The data was published in the journal PLoS One in 2015.PMID: 26431040

REFERENCE

Application Reference

Guendalina Olivero et al. Front Pharmacol 2021; 12 : 670158 The Depolarization-Evoked, Ca2+-Dependent Release of Exosomes From Mouse Cortical Nerve Endings: New Insights Into Synaptic Transmission.
Application : WB
Reactivity : Mouse
Averna M et al. PLoS One 2015; 10 (10) : e0139750 Physiological Roles of Calpain 1 Associated to Multiprotein NMDA Receptor Complex.
Application : WB
Reactivity : Human
Submit a Reference

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SDS
PBS.pdf
Glycerol.pdf
Package List Price ($)
$ 399