|Applications||ICC/IF, IHC-P, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||55 kDa (note)
|Positive Controls||293T , A431 , HeLa , A375 , GL261 , C8D30|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||TGF-beta activated kinase 1/MAP3K7 binding protein 1|
|Product Description||Rabbit Polyclonal antibody to TAB1 (TGF-beta activated kinase 1/MAP3K7 binding protein 1)|
|Background||The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]|
|Synonyms||3'-Tab1 antibody, MAP3K7IP1 antibody, MGC57664 antibody, TAB1 antibody, transforming growth factor beta-activated kinase-binding protein 1 antibody, mitogen-activated protein kinase kinase kinase 7-interacting protein 1 antibody, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 antibody, TAK1-binding protein 1 antibody, TGF-beta activated kinase 1/MAP3K7 binding protein 1 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human TAB1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Pig, Chicken, Rhesus Monkey|
|Predict Reactivity Note||Rat (95%), Pig (96%), Chicken (90%), Rhesus Monkey (100%)|