|Full Name||TGF-beta activated kinase 1/MAP3K7 binding protein 2|
|Product Description||Rabbit Polyclonal antibody to TAB2 (TGF-beta activated kinase 1/MAP3K7 binding protein 2)|
|Background||The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. [provided by RefSeq]|
|Synonyms||CHTD2 antibody, FLJ21885 antibody, KIAA0733 antibody, MAP3K7IP2 antibody, TAB2 antibody, TAB-2 antibody, TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 antibody, mitogen-activated protein kinase kinase kinase 7-interacting protein 2 antibody, TGF-beta-activated kinase 1-binding protein 2 antibody, TAK1-binding protein 2 antibody, TGF-beta activated kinase 1/MAP3K7 binding protein 2 antibody|
|Cellular Localization||Membrane; Peripheral membrane protein , Cytoplasm , cytosol |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human TAB2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Rat, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Human (100%), Rat (92%), Rhesus Monkey (99%), Bovine (95%)|