|Full Name||mitogen-activated protein kinase kinase kinase 7|
|Product Description||Rabbit polyclonal antibody to TAK1 (mitogen-activated protein kinase kinase kinase 7)|
|Background||The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]|
|Synonyms||MEKK7 antibody, TAK1 antibody, TGF1a antibody, MAP3K7 antibody, transforming growth factor-beta-activated kinase 1 antibody, TGF-beta activated kinase 1 antibody, mitogen-activated protein kinase kinase kinase 7 antibody, TGF-beta-activated kinase 1 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human TAK1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Xenopus laevis, Pig, Bovine|
|Predict Reactivity Note||Mouse (99%), Rat (99%), Zebrafish (88%), Xenopus laevis (96%), Pig (100%), Bovine (100%)|