|Full Name||nuclear RNA export factor 1|
|Product Description||Rabbit polyclonal antibody to TAP (nuclear RNA export factor 1)|
|Background||This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq]|
|Synonyms||DKFZp667O0311 antibody, MEX67 antibody, TAP antibody, NXF1 antibody, tip-associated protein antibody, nuclear RNA export factor 1 antibody, mRNA export factor TAP antibody, tip-associating protein antibody, tip associating protein antibody|
|Cellular Localization||Nucleus , nucleoplasm , Nucleus speckle , Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human TAP. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Chimpanzee, Bovine|
|Predict Reactivity Note||Mouse (87%), Rat (90%), Pig (85%), Chimpanzee (100%), Bovine (80%)|