|Full Name||transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)|
|Product Description||Rabbit Polyclonal antibody to TAP1 (transporter 1, ATP-binding cassette, sub-family B (MDR/TAP))|
|Background||The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. [provided by RefSeq]|
|Synonyms||APT1 Antibody , D6S114E Antibody , RING4 Antibody , ABC17 Antibody , transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) Antibody , PSF-1 Antibody , TAP1*0102N Antibody , PSF1 Antibody , ABCB2 Antibody , TAP1N Antibody|
|Cellular Localization||Endoplasmic reticulum membrane; Multi-pass membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human TAP1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Pig (85%), Bovine (83%)|