|Full Name||protein tyrosine phosphatase, non-receptor type 2|
|Product Description||Rabbit Polyclonal antibody to TCPTP (protein tyrosine phosphatase, non-receptor type 2)|
|Background||The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported. [provided by RefSeq]|
|Synonyms||PTPN2 Antibody , PTN2 Antibody , protein tyrosine phosphatase, non-receptor type 2 Antibody , TCELLPTP Antibody , PTPT Antibody , TC-PTP Antibody|
|Cellular Localization||Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human TCPTP. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Chicken, Bovine|
|Predict Reactivity Note||Rat (94%), Chicken (81%), Bovine (93%)|