|Full Name||anthrax toxin receptor 1|
|Product Description||Rabbit Polyclonal antibody to TEM8 (anthrax toxin receptor 1)|
|Background||This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq]|
|Synonyms||ATR antibody, FLJ10601 antibody, FLJ11298 antibody, FLJ21776 antibody, TEM8 antibody, ANTXR1 antibody, 2810405N18Rik antibody, tumor endothelial marker 8 antibody, anthrax toxin receptor 1 antibody, 2310008J16Rik antibody|
|Cellular Localization||Cell membrane , Cell projection , lamellipodium membrane , filopodium membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human TEM8. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Bovine|
|Predict Reactivity Note||Mouse (98%), Rat (98%), Bovine (98%)|