TET1 antibody [GT1462]
|Full Name||tet oncogene 1|
|Synonyms||CXXC6 antibody, FLJ10839 antibody, FLJ41442 antibody, KIAA1676 antibody, LCX antibody, bA119F7.1 antibody, TET1 antibody, methylcytosine dioxygenase TET1 antibody, leukemia-associated protein with a CXXC domain antibody, ten-eleven translocation 1 gene protein antibody, CXXC-type zinc finger protein 6 antibody, CXXC zinc finger 6 antibody, tet oncogene 1 antibody, CXXC finger 6 antibody, ten-eleven translocation-1 antibody|
|Product Description||Mouse Monoclonal antibody to TET1 (tet oncogene 1)|
|Background||Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain. |
|Applications||ICC/IF, IHC-P, IP, WB, ChIP assay|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Positive Controls||293T , FLAG-human TET1-transfected 293T cells|
|Predicted Target Size||235 kDa|
|Cellular Localization||Nucleus |
|Purification||Affinity purified by Protein G.|
|Storage Instruction||Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.|
|Notes||For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |