|Full Name||transcription factor EB|
|Product Description||Rabbit polyclonal antibody to TFEB (transcription factor EB)|
|Background||Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.|
|Synonyms||ALPHATFEB antibody, BHLHE35 antibody, TCFEB antibody, TFEB antibody, transcription factor EB antibody, class E basic helix-loop-helix protein 35 antibody, T-cell transcription factor EB antibody|
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human TFEB. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Rabbit, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (100%), Rat (100%), Rabbit (100%), Rhesus Monkey (100%), Bovine (100%)|