|Full Name||transforming growth factor, beta 2|
|Product Description||Rabbit Polyclonal antibody to TGF beta 2 (transforming growth factor, beta 2)|
|Background||This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]|
|Synonyms||TGFB2 Antibody , TGF-beta2 Antibody , transforming growth factor, beta 2 Antibody , LDS4 Antibody|
|Target||TGF beta 2|
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human TGF beta 2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rabbit, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (100%), Rabbit (100%), Rhesus Monkey (100%), Bovine (100%)|