|Full Name||transforming growth factor, beta receptor II (70/80kDa)|
|Product Description||Rabbit Polyclonal antibody to TGF beta Receptor 2 (transforming growth factor, beta receptor II (70/80kDa))|
|Background||This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq]|
|Synonyms||AAT3 antibody , FAA3 antibody , LDS1B antibody , LDS2B antibody , MFS2 antibody , RIIC antibody , TAAD2 antibody , TGF beta Receptor 2 antibody , TGF beta Receptor 2 antibody , TGFBR2 antibody , TGFR-2 antibody , TGFR2 antibody , TGFbeta RII antibody , transforming growth factor beta receptor II antibody|
|Cellular Localization||Membrane; Single-pass type I membrane protein|
|Target||TGF beta Receptor 2|
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human TGF beta Receptor 2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Rabbit, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (100%), Rat (100%), Rabbit (100%), Rhesus Monkey (100%), Bovine (100%)|