TGR5 antibody [C2C3], C-term
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||35 kDa (note)
|Positive Controls||A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||G protein-coupled bile acid receptor 1|
|Product Description||Rabbit Polyclonal antibody to TGR5 (G protein-coupled bile acid receptor 1)|
|Background||This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq]|
|Synonyms||BG37 antibody, GPCR19 antibody, GPR131 antibody, M-BAR antibody, MGC40597 antibody, TGR5 antibody, GPBAR1 antibody, hBG37 antibody, membrane-type receptor for bile acids antibody, G-protein coupled bile acid receptor 1 antibody, G-protein coupled receptor GPCR19 antibody, hGPCR19 antibody, membrane bile acid receptor antibody, G-protein coupled bile acid receptor BG37 antibody, G protein-coupled bile acid receptor 1 antibody|
|Cellular Localization||Cell membrane; Multi-pass membrane protein |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human TGR5. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rhesus Monkey (94%), Bovine (88%)|