|Full Name||THO complex 5|
|Product Description||Rabbit Polyclonal antibody to THOC5 (THO complex subunit 5 homolog)|
|Background||Component the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction beteen KSHV ORF57 protein and THOC4. UAP56 functions as a bridge between THOC4 and the THO complex. THOC5 in conjunction with THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA. May be involved in the differentiation of granulocytes and adipocytes. |
|Synonyms||C22orf19 antibody, Fmip antibody, PK1.3 antibody, fSAP79 antibody, THOC5 antibody, Fms-interacting protein antibody, PP39.2 antibody, placental protein 39.2 antibody, NF2/meningioma region protein pK1.3 antibody, THO complex subunit 5 homolog antibody, functional spliceosome-associated protein 79 antibody, hTREX90 antibody, THO complex 5 antibody|
|Cellular Localization||Nucleus (By similarity) , Cytoplasm (By similarity) |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human THOC5. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Chicken, Chimpanzee, Bovine|
|Predict Reactivity Note||Mouse (94%), Rat (94%), Chicken (84%), Chimpanzee (100%), Bovine (95%)|