|Product Description||Rabbit polyclonal antibody to Uromodulin|
|Background||This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq]|
|Synonyms||ADMCKD2 antibody, FJHN antibody, HNFJ antibody, HNFJ1 antibody, MCKD2 antibody, THGP antibody, THP antibody, UMOD antibody, uromodulin antibody, Tamm-Horsfall glycoprotein antibody, uromucoid antibody, "uromodulin (uromucoid, Tamm-Horsfall glycoprotein) antibody", tamm-Horsfall urinary glycoprotein antibody|
|Cellular Localization||Cell membrane; Lipid-anchor , GPI-anchor , Secreted |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Uromodulin. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Rat, Dog, Bovine|
|Predict Reactivity Note||Human (100%), Mouse (83%), Rat (85%), Dog (91%), Bovine (90%)|